Seminoe to Alcova Back Country Byway is located in south-central Wyoming about 32 miles southwest of Casper. The 64-mile route follows county roads across a mostly desert landscape between the small towns of Sinclair and Alcova. Features of the byway include Pathfinder Reservoir, Seminoe Reservoir, and the North Platte River.

Much of the land surrounding the byway is managed by the Bureau of Land Management (BLM). Several public campgrounds are along or near the byway. Dugway and Prior Flat campgrounds are managed by the BLM. Dugway has five sites (no charge) and Prior Flat has 15 sites for $7 per night. Alcova Lake Campground near the northern end of the byway has 200 sites, some with hookups. Camping is also available at Seminoe State Park for about $10 per night.